In 2375, tetryon pulse launchers were part of the armory of the Sovereign-class USS Enterprise-E. Captain Jean-Luc Picard took eight launchers on his mission to help the Ba'ku resist forced resettlement by the Son'a. (Star Trek: Insurrection)
According to the Decipher Starfleet Operations Manual, the tetryon pulse launcher was a phaser weapon developed by Starfleet in 2370. It was a 135 centimeter long hand-held version of the ship-mounted phaser cannon. The weapon used a beam of tetryon particles to bounce off the target providing range and vector information before firing the phaser bolt. The weapon featured similar destructive power to the shuttlecraft-mounted phaser emitters of the era.
In the video games Star Trek: Voyager - Elite Force and Star Trek: Elite Force II, tetryon pulse weapons designed by the Hirogen and the Klingons are available for the player, such as the tetryon pulse disruptor (β) and the tetryon gatling gun (β). Both are also capable of firing tetryon energy bursts that bounce off surfaces when magnetically constrained.