The Trouble with Tribbles could refer to:
- In-universe
- "The Trouble with Tribbles (book)", a book in existence during the 23rd century
- Real world
- "The Trouble with Tribbles", an episode from The Original Series
- The Trouble with Tribbles (reference novel), a book about the production of the episode of the same name
- The Trouble with Tribbles (fotonovel), a fotonovel adaptation of the episode
- CCG: The Trouble with Tribbles, an expansion of the Customizable Card Game
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