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Tobacco was an agricultural product on the planet Earth. To extract nicotine, a highly addictive and poisonous substance, humans smoked tobacco on Earth until at least the 21st century.

During the 19th century tobacco was on sale in a shop in the Irish village of Fair Haven, if the holoprogram Paris 042 is to be believed. (VOY: "Fair Haven")

Data would smoke a pipe when portraying Sherlock Holmes on the holodeck, as it was part of the role. (TNG: "Elementary, Dear Data", "Ship in a Bottle")

In 1930 New York City, a retail store sold tobacco and pipes. (TOS: "The City on the Edge of Forever")

Captain Jean Luc Picard lit a tobacco cigarette while portraying Dixon Hill on the holodeck. (TNG: "The Big Goodbye")

When Quark, Rom and Nog found themselves in 1940s Earth, virtually all of the Humans they encountered were smokers. Quark had a particularly negative reaction to the tobacco smoke. (DS9: "Little Green Men")

A shop advertising "tabac" (french for tobacco) was part of the Sainte Claire Holoprogram. (VOY: "The Killing Game")

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