(covers information from an alternate timeline)
In an alternate timeline, The Doctor diagnosed Captain Janeway with it while they were passing through Krenim territory in 2374. He did this after treating Janeway for third-degree burns as a result of her deliberately entering deflector control while a fire raged inside to reactivate the main deflector array while the USS Voyager was being bombarded by micrometeoroids. He classified this as reckless behavior and threatened to relieve her of duty if she did not allow The Doctor to monitor her.
Janeway refused, and was thus relieved of command. However, Janeway denied this order, even threatening to deactivate The Doctor, which he classified as yet another symptom of her instability. In the end, Janeway returned to duty knowing that she would face a court martial for refusing to follow The Doctor's orders. (VOY: "Year of Hell, Part II")