The USS Alka-Selsior (NCC-1404) was a 23rd century Federation starship operated by Starfleet.

In 2368, the Alka-Selsior was one of the many decommissioned ships stored at Surplus Depot Z15 in orbit of Qualor II. (TNG: "Unification I", "Unification II")

This studio model was one of the concept models designed by Nilo Rodis-Jamero and built at ILM by model builders Bill George and Steve Gawley for the USS Excelsior for Star Trek III: The Search for Spock. The name was an in-joke reference to the Alka-Seltzer brand-name of indigestion medicine, and a play on the name Excelsior. See for further information: Excelsior-class study models.
In the early 1960s, Richard C. Datin, Jr. built models for some of Alka-Seltzer's television commercials; Datin went on to become the very first Star Trek studio model maker in 1964. (The Enterprise NCC 1701 and The Model Maker, pp. 21-22)

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