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The USS Cairo (NCC-42136) was a Federation Excelsior-class starship operated by Starfleet during the 24th century.

In 2369, the Cairo was under the command of Captain Edward Jellico, and transported Vice admiral Alynna Nechayev to a rendezvous with the USS Enterprise-D. Jellico was then temporarily transferred to command the Enterprise for a special diplomatic mission to the Cardassian border. (TNG: "Chain Of Command, Part I")

Shortly thereafter, the Cairo was deployed to defend the Federation system Minos Korva when it was threatened by a potential Cardassian attack. Following the peaceful conclusion of the crisis, Captain Jellico returned to his command on the Cairo. (TNG: "Chain Of Command, Part II")

During the Dominion War, the Cairo was commanded by Captain Leslie Wong, and assigned to patrol the Romulan Neutral Zone in 2374. The ship was believed to have been ambushed and destroyed by Dominion forces who had crossed Romulan space to attack the the ship. (DS9: "In the Pale Moonlight")

Wreckage from the Cairo, along with another Excelsior-class vessel, eventually settled on a planet in the Delta Quadrant controlled by the Kazon-Oglamar. The wreckage was found in 2384 by Zero, a Medusan warrant officer in-training alongside several other ships. The rogue AI in charge of the nearby Kazon training facility on the planet suggested that it was responsible for the destruction of the Cairo rather than the Dominion, stating that it would scour the nearby Borg transwarp conduit for "recruits" to train as pilots, abducting ships and their crews. The best would survive initially, but they would inevitably fail and die. (PRO: "The Fast and the Curious")

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The Star Trek Encyclopedia, 4th ed., vol. 2, p. 327 listed the Cairo with the registry NCC-42136. In the Star Trek Encyclopedia, 3rd ed., p. 471, the Cairo was identified as an unnamed Excelsior-class starship that appeared in "Preemptive Strike". This information was omitted from the fourth edition. For the sake of continuity, this article assumes that the USS Gorkon, not the Cairo, remained Nechayev's flagship following the Borg incursion.

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