The USS Drake was a Federation light cruiser in service during the mid-24th century.

In 2364, Commander William Riker, then-XO of the USS Enterprise-D, declined Starfleet's offer to take command of the Drake.

Under the command of Captain Paul Rice, the Drake was destroyed by an ancient automated weapons platform known as the Echo Papa 607 while in orbit of Minos. (TNG: "The Arsenal of Freedom")

According to the Star Trek Encyclopedia this vessel was a Wambundu-class starship, with the registry NCC-20381.
This starship may have been named after the 16th century explorer Francis Drake.
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