There have been two Federation starships known to bear the name USS Grissom:
- USS Grissom (alternate reality), an alternate reality starship
- USS Grissom (24th century), a 24th century starship that saw action in the Dominion War
- USS Grissom (25th century), a 25th century starship
- USS Grissom (NCC-638), an Oberth-class starship
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