During the mid-2360s it was under the command of Captain L. Isao Telaka and operated with a crew compliment of twenty-six. At the time, the Lantree was classified as a class 6 supply ship and was armed with class 3 defensive armaments.
In 2365, the ship was assigned to Sector Gamma 7. Shortly after visiting Darwin Genetic Research Station, all 26 crewmembers fell victim to a mysterious aging disease that was later identified as geriatric phenomena during communications between Dr. Sara Kingsley and the USS Enterprise-D.
After answering her distress signal, the Enterprise found the Lantree adrift in space, her crew deceased, and subsequently quarantined the ship. After it became clear that the disease, caused by the immune systems of the children at Darwin, was highly contagious and could not be cured medically, the Enterprise destroyed the starship with one photon torpedo to prevent further transmission. (TNG: "Unnatural Selection")