The Nautilus fought in the Dominion War. In late 2374 she saw action at the First Battle of Chin'toka where she, along with the USS Hood and USS Tian An Men, assisted the USS Defiant in destroying the Cardassian orbital weapon platforms' shared power generator. (DS9: "Tears of the Prophets")
|USS Antares • USS Brattain • USS Lantree • USS Majestic • USS Nautilus • USS Reliant • USS Saratoga (NCC-1887) • USS Saratoga (NCC-31911) • USS ShirKahr • USS Sitak • USS Tian An Men • USS Trial • Unnamed|
The Nautilus' appearance in "Tears of the Prophets" was confirmed by John Gross and Karen Sickles of Digital Muse in a 25 June 1998 post, by DS9 Visual Effects Supervisor David Stipes, on the newsgroup alt.tv.star-trek.ds9. One of the Miranda-class ships that appeared in this sequence quite clearly bore the registry of NCC-1864.
According to the Star Trek Encyclopedia (4th ed., vol. 2, p. 68), the Nautilus was "named for the first submarine to reach the North Pole, as well as Captain Nemo's fictional vessel in Jules Verne's classic novel 20,000 Leagues Under the Sea."