The USS Proxima was a 24th century Federation starship operated by Starfleet.

In the early 2370s the Proxima was on an exploration mission in the Gamma Quadrant. The ship disappeared sometime prior to 2373 and was presumed to have been destroyed by the Dominion. (DS9: "In Purgatory's Shadow")

According to the Star Trek Encyclopedia (4th ed., vol. 2, p. 186), the Proxima was classified as a Nebula-class starship, with registry number NCC-61952. The book further noted that Proxima was named for Proxima Centauri, which was the nearest star from the Sol system. Proxima was Latin for "nearest".
The Proxima-class starship was seen in the video game Star Trek: Legacy.

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