While visiting Deep Space 9 during the Dominion War in 2375, the Sentinel listed a surplus graviton stabilizer on its manifest. Nog, acting on behalf of Chief O'Brien who needed the stabilizer for the USS Defiant, secured the unit in a complicated trade that brought a phaser emitter from the USS Musashi. (DS9: "Treachery, Faith and the Great River")
The starship class of the Sentinel was not known, but the games Star Trek: Invasion and Star Trek: Armada portray it as a Sovereign-class starship, while Pocket Books' Star Trek: SCE, War Stories, Book I stated the starship belonged to the Akira-class with the registry NCC-68455 and that Lieutenant Commander Sonya Gomez served aboard the vessel during the Dominion War.
In the Star Trek: Starfleet Academy game (set in the TOS film era), the Sentinel was a Miranda-class starship and crossed the Klingon neutral zone without authorization and engaged two Klingon Birds-of-Prey after it was believed that the Klingons were responsible for the mysterious destruction of a Federation colony.