In 2372, the Venture led a task force under the command of Admiral Hastur to reinforce Deep Space 9 when it was threatened by a Klingon attack. Sisko offered to talk to the captain of the Venture to secure Worf a position aboard, although Worf preferred to stay on Deep Space 9. (DS9: "The Way of the Warrior")
In 2374, the Venture participated in Operation Return, protecting the flank of the USS Defiant. The Venture was one of the first ships to arrive at Deep Space 9 after the Dominion retreat. (DS9: "Sacrifice of Angels")
|USS Challenger • USS Enterprise-D • USS Galaxy • USS Odyssey • USS Venture • USS Yamato • Unnamed|
The Venture in "The Way of the Warrior" (and episodes which reused that footage) was the four-foot USS Enterprise-D model built for the third season of Star Trek: The Next Generation. Although it was mostly unchanged from the Enterprise-D, the Venture retained the phaser arrays on the dorsal sides of its nacelles from when the model was modified into the future Enterprise from TNG: "All Good Things...", but they were turned around for the Venture. This was the last use of a physical model to represent the Galaxy-class, and the computer generated versions do not have the extra phasers.
The Venture's appearance in "Tears of the Prophets" was confirmed by John Gross and Karen Sickles of Digital Muse in a 25 June 1998 post, by DS9 Visual Effects Supervisor David Stipes, on the newsgroup alt.tv.star-trek.ds9.
The Venture was also the first Galaxy-class ship to have its full name emblazoned below the registry number on the ventral side of its saucer section,  which was carried over to other Galaxy-class ships such as the USS Challenger from VOY: "Timeless".
In the strategy game, Star Trek: Bridge Commander, the USS Venture was one of the ships the player has to rescue from a Cardassian attack.
In Star Trek Online, the Venture has been destroyed or decommissioned by 2409 and replaced by a Venture-class starship, NCC-71854-A; this ship was subsequently lost attempting to halt a Borg incursion into fluidic space.