The USS Yamaguchi (NCC-26510) was a 24th century Federation Ambassador-class starship operated by Starfleet.

In 2366, the Yamaguchi participated in the battle against the Borg at Wolf 359 in the fleet of forty Federation starships. She engaged the attacking Borg cube, alongside the USS Bellerophon, while the cube had tractored the USS Saratoga. (DS9: "Emissary")

The name Yamaguchi literally means "mountain mouth" in Japanese. A prefecture in Japan is named such and it is a common Japanese surname.
The Yamaguchi was the final appearance of the Ambassador class model. At the time of its retirement, the studio model bore the markings of both the USS Excalibur and Yamaguchi.

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