One of the first three runabouts assigned to Deep Space 9, the Yangtzee Kiang was delivered to the station by the USS Enterprise-D shortly before stardate 46388. Following the disappearance of the USS Rio Grande into what would later be known as the Bajoran wormhole, the Yangtzee Kiang, commanded by Kira Nerys, pursued a Cardassian Galor-class cruiser under the command of Gul Dukat, who was attempting to open the phenomenon. The Yangtzee Kiang was unsuccessful, and was witness to the wormhole's temporary sealing shortly after. (DS9: "Emissary")
Not long after, the Yangtzee Kiang was used by Bajoran terrorist Tahna Los in an attempt to destroy the wormhole using a bilitrium-based explosive device. After rendezvousing with a Klingon Bird-of-Prey, his attempt was thwarted by Major Kira. (DS9: "Past Prologue")
Major Kira later took the Yangtzee Kiang to Bajor where she contacted and then kidnapped Surmak Ren from the Ilvian Medical Complex in the planet's Northeastern District, and brought him back to Deep Space 9 (docking in Landing Pad 7) in order to find the cure for the aphasia virus. (DS9: "Babel")
Later that year, the Yangtzee Kiang took Kai Opaka through the wormhole to visit the Gamma Quadrant, where it crashed on a penal moon 0.35 light years from the Idran system terminus. The Yangtzee Kiang had received a mysterious subspace signal from an artificial satellite orbiting the moon and was fired upon in orbit. The vessel was unrecoverable. (DS9: "Battle Lines")
|Danube-class: USS Gander • USS Ganges • USS Mekong • USS Orinoco • USS Rio Grande • USS Rubicon • USS Shenandoah • USS Volga • USS Yangtzee Kiang • USS Yukon • NCC-73918 • Unnamed|
|Yellowstone-class: USS Yellowstone|
In the mission "Armistice" in Star Trek Online, the Yangtzee Kiang appears on the prison moon, but is heavily torn down and used by the prisoners as scrap.