Ultritium was an extremely powerful chemical explosive, virtually undetectable by conventional sensors and therefore frequently employed in covert operations. Ninety isotons of enriched ultritium had enough explosive power to destroy almost anything within a radius of eight hundred kilometers. (DS9: "A Time to Stand") A high-yield version of this explosive was evora oxide. (TNG: "Night Terrors")

In 2346, Kira Nerys, brought to the past by the Orb of Time, planted a bomb made from ultritium resin aboard Terok Nor in an assassination attempt on Gul Dukat. (DS9: "Wrongs Darker Than Death or Night")

In 2365, a pair of Antedian assassins posing as a diplomatic delegation attempted to bomb a conference on Pacifica using ultritium. Their plot nearly succeeded, were it not for Ambassador Lwaxana Troi, who read their minds. (TNG: "Manhunt")

An ultritium-based auto-destruct device was used to destroy the Romulan scout ship Pi after it crash-landed on Galorndon Core in 2366. (TNG: "The Enemy")

Ultritium was on board the USS Enterprise-D when it was trapped inside a Tyken's Rift in 2367. It was listed among the ship's inventory as Ultritium 283 "Industrial chemical explosive used in mining applications. Intended for precision-charge patterns using standard microwave pulse ignition devices." and Ultritium 342 "High-yield version of standard industrial ultritium, used in terraforming applications. Activated with microwave pulse ignition devices. Intended for use when nuclear explosives are not desirable." (TNG: "Night Terrors")

The Dominion mined ultritium from a rocky gas giant moon in the Gamma Quadrant, before converting it into Internment Camp 371. (DS9: "In Purgatory's Shadow") The Jem'Hadar employed ultritium concussion shells to bombard a downed Jem'Hadar attack ship captured by Captain Benjamin Sisko in early 2373. However, the shells were merely an intimidation tactic and caused no harm to the ship. (DS9: "The Ship")

During the Dominion War, an undercover team led by Captain Sisko destroyed the Dominion's primary ketracel-white storage facility using enriched ultritium, concealed inside an empty canister of white. (DS9: "A Time to Stand")

In 2375, Captain Jean-Luc Picard was planning to bring seven metric tons of ultritium explosives to the Ba'ku planet, along with eight tetryon pulse launchers and ten isomagnetic disintegrators, in order to keep the Ba'ku from being forcibly removed by the Federation and the Son'a. (Star Trek: Insurrection)

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