University of California, Berkeley is an institution of higher learning located on Earth, near San Francisco in Berkeley, California. It was the home of the Free Speech Movement of the 1960s.

In 2152, the Enterprise receives an urgent message from Admiral Forrest, relayed through the Vulcan ship Nyran under Captain Tavek. With orders to act as if Captain Archer is still aboard, Commander Tucker pretends to be the Captain in order to receive the message: "Cal beat Stanford 7 to 3." (ENT: "The Seventh")

During a time-travel mission to 1986, James T. Kirk informed (not entirely truthfully) Dr. Gillian Taylor that Spock's aberrant behavior was result of his involvement with the Free Speech Movement and his overindulgence in "LDS" [sic]. (Star Trek IV: The Voyage Home)

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