Uranium is a radioactive element that was used as fuel for nuclear reactors and nuclear weapons. One important Federation source of uranium was the planet Janus VI. (TOS: "The Devil in the Dark")

In 1986, a time traveling Pavel Chekov and Nyota Uhura were assigned to the "uranium problem" (collecting photons from a nuclear vessel) by James T. Kirk. (Star Trek IV: The Voyage Home)

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