A ventricle was the chamber which received blood from the atrium and pumped it out, away from the heart. Ventricular fibrillation, a condition affecting the ventricles, could lead to death. (ENT: "Dead Stop")

In 2369, Ibudan murdered his clone by perforating the lower ventricle of the clone's heart with a knife. (DS9: "A Man Alone")

In 2374, Dejaren reached into B'Elanna Torres' chest and grabbed her heart, perforating her fourth ventricle. (VOY: "Revulsion")

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