A weekend was the period at the end of a work week, typically encompassing Saturday and Sunday. Weekends bracketed at either or both ends by holidays were called long weekends.
In 1957, Billy invited the Mestral to attend a ball game over the weekend. He declined to attend. (ENT: "Carbon Creek")
While traveling back in time to 1996, Rain Robinson asked Tom Paris on a date, first for the following night and then the upcoming weekend, before guessing he might have been married when he turned her down. (VOY: "Future's End, Part II")
Hoshi Sato was released from Starfleet Training Command after two months in approximately the late 2140s for bad conduct after breaking the arm of her company commander when he stopped the floating poker game she ran on the weekends. (ENT: "Observer Effect")
In the mirror universe in 2155, Hoshi Sato told Maximilian Forrest that when he took a comfortable desk job at Headquarters on Earth, they would spend weekends together. (ENT: "In a Mirror, Darkly")
In 2257, Hugh Culber scolded Paul Stamets that all his time, including weekends and nights, in his lab. (DIS: "If Memory Serves")
When Seven of Nine was six years old in 2350, she spent the weekend with her aunt Irene Hansen. (VOY: "Author, Author")
Sometime in the 2350s, B'Elanna Torres went on a camping trip with her father, uncle Carl Torres, cousins Elizabeth, Dean, and Michael Torres. (VOY: "Lineage")
One weekend in approximately 2351, an intoxicated Cadet Benjamin Sisko got into a debate with a Vulcan cadet, Solok, on whether Vulcans were naturally superior to Humans and other "emotionally handicapped" species. (DS9: "Take Me Out to the Holosuite")
Tom Paris lost his virginity when he was seventeen sometime in the 2360s in his bedroom when his parents were away for the weekend. (VOY: "Threshold")
In 2368, when Admiral Kennelly spoke with a Cardassian liaison over a weekend about the recent the alleged Bajoran terrorist attack on the Solarion IV colony, he claimed to have gotten the common cold from him. (TNG: "Ensign Ro")
In 2373, Major Kira Nerys commented she would like to spend the weekend at the Golian Spa. (DS9: "Children of Time")
In 2377, B'Elanna Torres made plans to spend the weekend with her husband Tom Paris, arranging for holodeck time by trading with other members of the crew. She was upset when Paris cancelled the weekend in order to join a race, but realized she could still spend time with him during the race. (VOY: "Drive")
In 2380, Quimp and his wife were planning to go to Risa over a weekend. (LD: "Envoys")
That same year, Commander Jack Ransom had a report for a classified mission that included intelligence on guard positioning over the weekend. (LD: "Veritas")
Later that year, the sentient computer Vexilon reminisced about a weekend wherein his designers evolved into fifth dimensional non-corporeal lifeforms and left him alone. (LD: "In the Cradle of Vexilon")
In an alternate future of 2404, a captain Harry Kim compared his recent a four-year deep space assignment to a long weekend when considered alongside his time on the USS Voyager. (VOY: "Endgame")
In the holo-novel program Crisis Point II: Paradoxus, the character Helena Gibson scolded the protagonist Bucephalus Dagger for not calling her back after a weekend on Risa. (LD: "Crisis Point 2: Paradoxus")