When the Vorta clone Weyoun 7 was activated, he ordered a massive search to prevent Weyoun 6 from defecting to the Federation. Weyoun 7 was contacted by his predecessor so he could witness Weyoun 6 voluntarily activate his termination implant, thus removing the reason the Jem'Hadar were attacking Odo's runabout. Once this was done, Weyoun 7 called off the attack and wished Odo "a safe and pleasant journey back to DS9." (DS9: "Treachery, Faith and the Great River")
By late 2375, Weyoun 7 was in charge of a massive research project to find a cure for the Founders' disease. He also supported the Female Changeling in her negotiations to arrange the alliance between the Dominion and the Breen Confederacy.
While attending to the transfer of two captured Starfleet officers, Worf and Ezri Dax, from a Breen ship to Dominion custody, he mentioned that he wished them to be held in a cell together due to his desire to see them "comfort each other" sexually. During a later meeting with the captured Worf and Dax, he tried to goad Dax into cooperating with a further interrogation by referencing her feelings for Bashir – to which Worf responded by abruptly breaking his neck, killing Weyoun 7 instantly.
Damar, who was escorting Weyoun, reacted only by stopping his guards from taking action against Worf and then bursting into laughter, amused by both the meaninglessness of killing a Weyoun (as another clone would quickly take his place) and that Worf missed the opportunity to kill him, a far more valuable target. (DS9: "Strange Bedfellows")
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Weyoun 7 was portrayed by Jeffrey Combs, in his fourth of five Weyoun appearances.