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Withdrawal was a medical condition resulting from lack of access to an addictive narcotic substance.

In 2154, T'Pol experienced withdrawal while trying to break her addiction to trellium-D. (ENT: "Damage", "The Forgotten")

Symptoms of felicium withdrawal were sufficiently onerous to be mistaken for the disease it was supposed to cure. Bound by the Prime Directive to not interfere with the interplanetary exploitation by the planet Brekka over the neighboring planet Ornaran with this substance, Captain Jean-Luc Picard instead refused to assist repairing the necessary ships for the trade to cut it off and force the Ornarans off their collective addiction. (TNG: "Symbiosis")

As a result, the Ornarans faced an arduous period of mass withdrawal due to Picard forcing them to go 'cold turkey' until the effects passed for their ultimate benefit to their collective health. However, because Starfleet abandoned them for all the years they were going through withdrawal without support, they respectfully decline any support Captain Freeman offers, since they didn't want anything to do with Starfleet. (LD: "Trusted Sources")

In 2371, Doctor Julian Bashir diagnosed a Jem'Hadar youth with withdrawal from Ketracel-white after he came into the infirmary complaining of a headache, chest pain and nausea. (DS9: "The Abandoned")

In 2372, Bashir tried to cure some addicted Jem'Hadar. (DS9: "Hippocratic Oath") Two years later, he defended his actions to Luther Sloan, saying, "I'm a doctor. They were suffering from withdrawal." (DS9: "Inquisition")

Also in 2374, Keevan surmised that a Starfleet engineer would have more success at fixing a communications system than a Jem'Hadar suffering from withdrawal. (DS9: "Rocks and Shoals")

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